Invention Application
WO2014101113A1 PIPERAZINE-SUBSTITUTED 7-METHOXY-[1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES
审中-公开
哌嗪取代的具有A2A拮抗剂性质的7-甲氧基 - [1,2,4]三唑[1,5-C]喹唑啉-5-胺化合物
- Patent Title: PIPERAZINE-SUBSTITUTED 7-METHOXY-[1,2,4]TRIAZOLO[1,5-C]QUINAZOLIN-5-AMINE COMPOUNDS WITH A2A ANTAGONIST PROPERTIES
- Patent Title (中): 哌嗪取代的具有A2A拮抗剂性质的7-甲氧基 - [1,2,4]三唑[1,5-C]喹唑啉-5-胺化合物
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Application No.: PCT/CN2012/087851Application Date: 2012-12-28
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Publication No.: WO2014101113A1Publication Date: 2014-07-03
- Inventor: ALI, Amjad , LO, Michael Man-Chu , LIM, Yeon-Hee , STAMFORD, Andrew , KUANG, Rongze , TEMPEST, Paul , YU, Younong , BERLIN, Michael , TING, Pauline , ZHOU, Gang , YU, Tao , BOYCE, Christopher , KELLY, Joseph Michael , TAGAT, Jayaram R. , ZHENG, Junying , HUANG, Xianhai , ZHOU, Wei , KIM, Jae-Hun , ZORN, Nicolas , XIAO, Dong , GALLO, Gioconda V. , WON, Walter , WU, Heping , ANAND, Rajan
- Applicant: MERCK SHARP & DOHME CORP. , ALI, Amjad , LO, Michael Man-Chu , LIM, Yeon-Hee , STAMFORD, Andrew , KUANG, Rongze , TEMPEST, Paul , YU, Younong , BERLIN, Michael , TING, Pauline , ZHOU, Gang , YU, Tao , BOYCE, Christopher , KELLY, Joseph Michael , TAGAT, Jayaram R. , ZHENG, Junying , HUANG, Xianhai , ZHOU, Wei , KIM, Jae-Hun , ZORN, Nicolas , XIAO, Dong , GALLO, Gioconda V. , WON, Walter , WU, Heping , ANAND, Rajan
- Applicant Address: 126 East Lincoln Avenue Rahway, New Jersey 07065 US
- Assignee: MERCK SHARP & DOHME CORP.,ALI, Amjad,LO, Michael Man-Chu,LIM, Yeon-Hee,STAMFORD, Andrew,KUANG, Rongze,TEMPEST, Paul,YU, Younong,BERLIN, Michael,TING, Pauline,ZHOU, Gang,YU, Tao,BOYCE, Christopher,KELLY, Joseph Michael,TAGAT, Jayaram R.,ZHENG, Junying,HUANG, Xianhai,ZHOU, Wei,KIM, Jae-Hun,ZORN, Nicolas,XIAO, Dong,GALLO, Gioconda V.,WON, Walter,WU, Heping,ANAND, Rajan
- Current Assignee: MERCK SHARP & DOHME CORP.,ALI, Amjad,LO, Michael Man-Chu,LIM, Yeon-Hee,STAMFORD, Andrew,KUANG, Rongze,TEMPEST, Paul,YU, Younong,BERLIN, Michael,TING, Pauline,ZHOU, Gang,YU, Tao,BOYCE, Christopher,KELLY, Joseph Michael,TAGAT, Jayaram R.,ZHENG, Junying,HUANG, Xianhai,ZHOU, Wei,KIM, Jae-Hun,ZORN, Nicolas,XIAO, Dong,GALLO, Gioconda V.,WON, Walter,WU, Heping,ANAND, Rajan
- Current Assignee Address: 126 East Lincoln Avenue Rahway, New Jersey 07065 US
- Agency: LIU, SHEN & ASSOCIATES
- Main IPC: C07D487/04
- IPC: C07D487/04 ; A61K31/4196 ; A61K31/517 ; A61K31/519 ; A61P25/28
Abstract:
Disclosed are compounds of Formula (A), as defined herein, which have binding activity for an A 2A -receptor and are believed to be useful for treatment or management of CNS diseases or conditions which can be treated or managed using compounds which have A 2A receptor antagonist activity.
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