发明申请
- 专利标题： METHODS AND COMPOSITIONS FOR DUAL GLYCAN BINDING AAV VECTORS
- 专利标题（中）： 双糖结合AAV载体的方法和组合
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申请号： PCT/US2014/028545申请日： 2014-03-14
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公开(公告)号： WO2014144229A1公开(公告)日： 2014-09-18
- 发明人: ASOKAN, Aravind , SAMULSKI, Richard
- 申请人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
- 申请人地址： 308 Bynum Hall Campus Box 4105 Chapel Hill, North Carolina 27599 US
- 专利权人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
- 当前专利权人： THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
- 当前专利权人地址： 308 Bynum Hall Campus Box 4105 Chapel Hill, North Carolina 27599 US
- 代理机构： MILLER, Mary, L. et al.
- 优先权： US61/802,111 20130315
- 主分类号： A61K48/00
- IPC分类号： A61K48/00 ; C12N5/10 ; C07K14/075
摘要：
The present invention provides methods and compositions comprising an adeno-associated virus (AAV) capsid protein, comprising one or more amino acids substitutions, wherein the substitutions introduce a new glycan binding site into the AAV capsid protein.
