An RF (e.g., GNSS) interference mitigation system and method uses a switchable bank of filters for selectively blocking signals in predetermined bandwidths based on detecting strong, interfering signals with an interference detection circuit including a sniffer antenna. A low- strength RF (e.g., GNSS) system can be combined with a spectrally-close high-strength, telecommunications receiver system for cooperative control. Alternatively, an RF receiver can detect tones, changes in DC bias or level changes to activate a filter selection switch.