发明申请
- 专利标题： ANTISENSE OLIGOMERS AND CONJUGATES TARGETING PCSK9
- 专利标题（中）： 抗生素低聚物和靶向PCSK9
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申请号： PCT/EP2014063757申请日： 2014-06-27
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公开(公告)号： WO2014207232A4公开(公告)日： 2015-03-19
- 发明人: ALBÆK NANNA , HEDTJÄRN MAJ , LINDHOLM MARIE , NIELSEN NIELS FISKER , PETRI ANDREAS , RAVN JACOB
- 申请人： ROCHE INNOVATION CT COPENHAGEN AS
- 专利权人： ROCHE INNOVATION CT COPENHAGEN AS
- 当前专利权人： ROCHE INNOVATION CT COPENHAGEN AS
- 优先权： EP13174092 2013-06-27; EP13192930 2013-11-14; EP13192938 2013-11-14; EP14153253 2014-01-30; EP14168331 2014-05-14
- 主分类号： C12N15/113
- IPC分类号： C12N15/113 ; A61K31/712 ; A61P3/06
摘要：
The present invention relates to oligomeric compounds and conjugates thereof that target Proprotein Convertase Subtilisin/Kexin type 9 (PCSK9) PCSK9 mRNA in a cell, leading to reduced expression of PCSK9. Reduction of PCSK9 expression is beneficial for a range of medical disorders, such as hypercholesterolemia and related disorders.
IPC分类:
