Invention Application
WO2015006762A1 METHODS AND COMPOSITIONS FOR EXPANDING LONG-TERM HEMATOPOIETIC STEM CELL POPULATIONS
审中-公开
用于扩展长期HEMATOPOIETIC干细胞群体的方法和组合物
- Patent Title: METHODS AND COMPOSITIONS FOR EXPANDING LONG-TERM HEMATOPOIETIC STEM CELL POPULATIONS
- Patent Title (中): 用于扩展长期HEMATOPOIETIC干细胞群体的方法和组合物
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Application No.: PCT/US2014/046498Application Date: 2014-07-14
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Publication No.: WO2015006762A1Publication Date: 2015-01-15
- Inventor: ZHOU, Daohong , LUO, Yi , SHAO, Lijian , FENG, Wei , CHANG, Jianhui
- Applicant: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS , ZHOU, Daohong , LUO, Yi , SHAO, Lijian , FENG, Wei , CHANG, Jianhui
- Applicant Address: 2404 North University Avenue Little Rock, Arkansas 72207 US
- Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS,ZHOU, Daohong,LUO, Yi,SHAO, Lijian,FENG, Wei,CHANG, Jianhui
- Current Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS,ZHOU, Daohong,LUO, Yi,SHAO, Lijian,FENG, Wei,CHANG, Jianhui
- Current Assignee Address: 2404 North University Avenue Little Rock, Arkansas 72207 US
- Agency: RILEY-VARGAS, Rebecca et al.
- Priority: US61/845,952 20130712
- Main IPC: A61K35/12
- IPC: A61K35/12 ; C12N5/0789 ; C12N5/0786
Abstract:
The invention generally features compositions and methods for expanding long term hematopoietic stem cells (HSCs) in a population of cells. In particular, the invention relates to a method of expanding long term HSCs by culturing an initial population of HSCs with macrophages that promote self-renewal of long term HSCs. The expanded cell population provides a source of cells for therapeutic treatments utilizing HSC transplantation.
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