A complete remedy for AIDS is difficult to obtain. As such, a useful process was designed to search for an anti-HIVi agent that has an immuno response modification activity capable of releasing immuno suppression, activating killer cells to destroy persistent infection cells, elevating antibody titer to activate ADCC activity, and vice versa. The process consists of 4 elements: guinea pig or mouse peritoneal derived adherent macrophages/monocytes as effector cells; cyclophosphamide as an immuno suppressor; chicken RBC as target cells; and the anti-HIVi agent candidate to be examined. Immunovir and components were isolated from Pyrus serotina Rehder and other species of Rosaceae by column chromatography. Another useful process is the comparison of fluorescent antibody (FA) titer patterns among one round, two round, and non-medicated infected monkeys. The results of such processes can show that the anti-HIVi agent, such as these immunovirs, are noble candidates for the complete remedy of AIDS.