- 专利标题： LIPID NANOPARTICLE VACCINE ADJUVANTS AND ANTIGEN DELIVERY SYSTEMS
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申请号： PCT/US2015/017007申请日： 2015-02-23
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公开(公告)号： WO2015130584A2公开(公告)日： 2015-09-03
- 发明人: GINDY, Marian , CASIMIRO, Danilo, R. , BETT, Andrew , TER MEULEN, Jan, H.
- 申请人： MERCK SHARP & DOHME CORP. , GINDY, Marian , CASIMIRO, Danilo, R. , BETT, Andrew , TER MEULEN, Jan, H.
- 申请人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 US
- 专利权人： MERCK SHARP & DOHME CORP.,GINDY, Marian,CASIMIRO, Danilo, R.,BETT, Andrew,TER MEULEN, Jan, H.
- 当前专利权人： MERCK SHARP & DOHME CORP.,GINDY, Marian,CASIMIRO, Danilo, R.,BETT, Andrew,TER MEULEN, Jan, H.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 US
- 代理机构： MERCK SHARP & DOHME CORP.
- 优先权： US61/944,336 20140225
- 主分类号： A61K39/12
- IPC分类号： A61K39/12
摘要：
The instant invention provides for novel lipid nanoparticle (LNP) formulations, containing cationic lipids, for use as vaccine adjuvants and/or as antigen delivery systems. It is an object of the instant invention to provide LNP formulations that demonstrate enhancements in humoral and cellular immunogenicity of vaccine antigens, particularly subunit vaccine antigens, when utilized alone or in combination with immunostimulatory agents (e.g. small molecule or oligonucleotide TLR agonists). The instant invention further identifies physical and chemical properties of the LNP formulations that can be manipulated to enhance antigen efficiency and adjuvant tolerability in vivo.
