发明申请
WO2015130584A3 LIPID NANOPARTICLE VACCINE ADJUVANTS AND ANTIGEN DELIVERY SYSTEMS
审中-公开
脂质纳米颗粒疫苗佐剂和抗原递送系统
- 专利标题： LIPID NANOPARTICLE VACCINE ADJUVANTS AND ANTIGEN DELIVERY SYSTEMS
- 专利标题（中）： 脂质纳米颗粒疫苗佐剂和抗原递送系统
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申请号： PCT/US2015017007申请日： 2015-02-23
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公开(公告)号： WO2015130584A3公开(公告)日： 2015-11-19
- 发明人: GINDY MARIAN , CASIMIRO DANILO R , BETT ANDREW , TER MEULEN JAN H
- 申请人： MERCK SHARP & DOHME , GINDY MARIAN , CASIMIRO DANILO R , BETT ANDREW , TER MEULEN JAN H
- 专利权人： MERCK SHARP & DOHME,GINDY MARIAN,CASIMIRO DANILO R,BETT ANDREW,TER MEULEN JAN H
- 当前专利权人： MERCK SHARP & DOHME,GINDY MARIAN,CASIMIRO DANILO R,BETT ANDREW,TER MEULEN JAN H
- 优先权： US201461944336 2014-02-25
- 主分类号： A61K9/127
- IPC分类号： A61K9/127
摘要：
The instant invention provides for novel lipid nanoparticle (LNP) formulations, containing cationic lipids, for use as vaccine adjuvants and/or as antigen delivery systems. It is an object of the instant invention to provide LNP formulations that demonstrate enhancements in humoral and cellular immunogenicity of vaccine antigens, particularly subunit vaccine antigens, when utilized alone or in combination with immunostimulatory agents (e.g. small molecule or oligonucleotide TLR agonists). The instant invention further identifies physical and chemical properties of the LNP formulations that can be manipulated to enhance antigen efficiency and adjuvant tolerability in vivo.
