Invention Application
WO2015155323A1 BR2 ANTAGONIST FOR USE IN THE PREVENTION OF THE HYPOTENSIVE EFFECT OF PATIENT TREATED WITH ANGIOTENSIN-CONVERTING ENZYME INHIBITORS (ACEI)
审中-公开
BR2拮抗剂用于预防用抗生素转化酶抑制剂（ACEI）治疗患者的高血压效应
- Patent Title: BR2 ANTAGONIST FOR USE IN THE PREVENTION OF THE HYPOTENSIVE EFFECT OF PATIENT TREATED WITH ANGIOTENSIN-CONVERTING ENZYME INHIBITORS (ACEI)
- Patent Title (中): BR2拮抗剂用于预防用抗生素转化酶抑制剂（ACEI）治疗患者的高血压效应
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Application No.: PCT/EP2015/057800Application Date: 2015-04-10
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Publication No.: WO2015155323A1Publication Date: 2015-10-15
- Inventor: CHARBONNEAU, Hélène , MAYEUR, Nicolas , TACK, Ivon
- Applicant: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITÉ PAUL SABATIER TOULOUSE III , CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE , ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (APHP)
- Applicant Address: 101, rue de Tolbiac 75013 Paris FR
- Assignee: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE),UNIVERSITÉ PAUL SABATIER TOULOUSE III,CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE,ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (APHP)
- Current Assignee: INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE),UNIVERSITÉ PAUL SABATIER TOULOUSE III,CENTRE HOSPITALIER UNIVERSITAIRE DE TOULOUSE,ASSISTANCE PUBLIQUE-HÔPITAUX DE PARIS (APHP)
- Current Assignee Address: 101, rue de Tolbiac 75013 Paris FR
- Agency: HIRSCH, Denise
- Priority: EP14305523.4 20140410
- Main IPC: A61K38/08
- IPC: A61K38/08 ; A61K31/402 ; A61K31/445 ; A61K31/4709 ; A61K31/496 ; A61P9/00
Abstract:
The present invention relates to a method of preventing and/or treating the hypotensive effect of angiotensin-converting enzyme inhibitors (ACEl) in a patient treated with ACEl, said patient being under a critical condition. More specifically, it concerns the use of a Bradykinin 2 receptor (BR2) antagonist for the prevention and treatment of the hypotensive effect of ACEl in a patient treated with ACEl undergoing emergency anaesthesia or shock resuscitation like hypovolemic shock (i.e. hemorrhagic shock (HS), or vasoplegic shock (i.e. septic shock).
Information query
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