A safety and availability manifold system for a petroleum downstream complexes and petro-chemical industry is disclosed, the manifold system having at least one intake and at least one exhaust, the manifold system comprising' at least two automatic valves coupled to one another so as to form series and parallel redundancies and at least two manual operated valves corresponding to the two automatic valves that form series and parallel redundancies the manual operated valves being operatively coupled to an automatic valve in a hot swapping manner. The manifold system further includes at least one shuttle valve operatively coupled to the two automatic valves, an actuator with a rack and pinion arrangement connected to springs attached at opposite ends is operatively connected to the shuttle valve, one or more electrically-operated pressure sensors and one or more indicators that are electrically coupled to the two automatic valves to indicate an availability status thereof.