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发明申请
WO2015160247A1 METHOD FOR ASSESSING AND TREATING OR PREVENTING IMPAIRED PLASMA POLAR LIPID LEVELS 审中-公开
评估和处理或预防等离子体极性脂质水平的方法

METHOD FOR ASSESSING AND TREATING OR PREVENTING IMPAIRED PLASMA POLAR LIPID LEVELS
摘要：
The invention pertains to the use of a preparation for the manufacture of a composition for preventing or treating impaired plasma levels of one or more polar lipids such as phosphatidylcholines [PC] selected from the group consisting of phosphatidylcholine diacyl C36:6 [PC aa C36:6], phosphatidylcholine diacyl C38:0 [PC aa C38:0], phosphatidylcholine diacyl C38:6 [PC aa C38:6], phosphatidylcholine diacyl C40:6 [PC aa C40:6] and phosphatidylcholine acyl-alkyl C40:6 [PC ae C40:6] in a preclinical AD or MCI subject or a subject with a high likelihood of developing AD or MCI, and wherein said subject is administered with a composition comprising at least one, preferably at least two, most preferably all B vitamins selected from the group consisting of vitamin B6, vitamin B12 and vitamin B9.
摘要（中）：

本发明涉及用于制备用于预防或治疗一种或多种极性脂质受损血浆水平的组合物的制剂的用途，所述极性脂质如磷脂酰胆碱[PC]选自磷脂酰胆碱二酰基C36：6 [PCaa C36： 6]，磷脂酰胆碱二酰基C38：0 [PCaa C38：0]，磷脂酰胆碱二酰基C38：6 [PC aa C38：6]，磷脂酰胆碱二酰基C40：6 [PCaa C40：6]和磷脂酰胆碱酰基 - 烷基C40： PC ae C40：6]在临床前AD或MCI受试者或具有高发展AD或MCI可能性的受试者中，并且其中所述受试者被给予包含至少一种，优选至少两种，最优选全部B族维生素 选自维生素B6，维生素B12和维生素B9组成。

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