发明申请
WO2016001698A1 PROCESS FOR POLARIZING NMR ACTIVE NUCLEI, POLARIZING AMPLIFIER AND APPARATUS FOR POLARIZING NMR ACTIVE NUCLEI
审中-公开
用于极化NMR活性核的方法，极化放大器和用于偏振NMR活性核的装置
- 专利标题： PROCESS FOR POLARIZING NMR ACTIVE NUCLEI, POLARIZING AMPLIFIER AND APPARATUS FOR POLARIZING NMR ACTIVE NUCLEI
- 专利标题（中）： 用于极化NMR活性核的方法，极化放大器和用于偏振NMR活性核的装置
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申请号： PCT/IB2014/002163申请日： 2014-06-30
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公开(公告)号： WO2016001698A1公开(公告)日： 2016-01-07
- 发明人: ROSSINI, Aaron , ZAGDOUN, Alexandre , KUBICKI, Dominik , EMSLEY, Lyndon , LESAGE, Anne
- 申请人： CENTRE NATIONAL DE LA RECHERCHER SCIENTIFIQUE - CNRS , UNIVERSITÉ CLAUDE BERNARD LYON 1 , ECOLE NORMALE SUPÉRIEURE DE LYON
- 申请人地址： 3, rue Michel-Ange F-75794 Paris Cedex 16 FR
- 专利权人： CENTRE NATIONAL DE LA RECHERCHER SCIENTIFIQUE - CNRS,UNIVERSITÉ CLAUDE BERNARD LYON 1,ECOLE NORMALE SUPÉRIEURE DE LYON
- 当前专利权人： CENTRE NATIONAL DE LA RECHERCHER SCIENTIFIQUE - CNRS,UNIVERSITÉ CLAUDE BERNARD LYON 1,ECOLE NORMALE SUPÉRIEURE DE LYON
- 当前专利权人地址： 3, rue Michel-Ange F-75794 Paris Cedex 16 FR
- 代理机构： THIBAULT, Jean-Marc
- 主分类号： G01R33/28
- IPC分类号： G01R33/28 ; G01R33/62
摘要：
The invention provides for a process for polarizing NMR active nuclei within an analyte of interest by dynamic nuclear polarization (DNP), said process comprising the steps of: a. providing a polarizing solution; b. contacting the analyte of interest with the polarizing solution; c. submitting the polarizing solution to DNP conditions, characterized in that it comprises the step of providing a DNP amplifying solid material dispersed or immersed in the polarizing solution, in that the DNP amplifying solid material has a real component of relative permittivity higher than that of the polarizing solution, and in that the volumetric fraction of the DNP amplifying solid material in the final mixture of polarizing solution, analyte and DNP amplifying material is in the range of 10 to 80%, preferably between 15 to 75%, most preferably between 40 to 70 %.
