Invention Application
- Patent Title: COMPOSITIONS AND METHODS FOR INHIBITING BMP
- Patent Title (中): 用于抑制BMP的组合物和方法
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Application No.: PCT/US2015/040366Application Date: 2015-07-14
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Publication No.: WO2016011019A1Publication Date: 2016-01-21
- Inventor: LEE, Arthur , MCKEW, John, C. , PATEL, Paresma, R. , YU, Paul, B. , MOHEDAS, Agustin, H. , SANDERSON, Philip, E. , ZHENG, Wei , HUANG, Xiuli , CUNY, Gregory, D.
- Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , LEE, Arthur , MCKEW, John, C. , PATEL, Paresma, R. , YU, Paul, B. , MOHEDAS, Agustin, H. , SANDERSON, Philip, E. , ZHENG, Wei , HUANG, Xiuli , UNIVERSITY OF HOUSTON SYSTEM
- Applicant Address: 75 Francis Street Boston, MA 02115 US
- Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.,THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES,LEE, Arthur,MCKEW, John, C.,PATEL, Paresma, R.,YU, Paul, B.,MOHEDAS, Agustin, H.,SANDERSON, Philip, E.,ZHENG, Wei,HUANG, Xiuli,UNIVERSITY OF HOUSTON SYSTEM
- Current Assignee: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.,THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES,LEE, Arthur,MCKEW, John, C.,PATEL, Paresma, R.,YU, Paul, B.,MOHEDAS, Agustin, H.,SANDERSON, Philip, E.,ZHENG, Wei,HUANG, Xiuli,UNIVERSITY OF HOUSTON SYSTEM
- Current Assignee Address: 75 Francis Street Boston, MA 02115 US
- Agency: HALSTEAD, David P. et al.
- Priority: US62/024,870 20140715
- Main IPC: C07D487/04
- IPC: C07D487/04 ; A61K31/519 ; A61P9/00 ; A61P3/06 ; A61P29/00 ; A61P31/00 ; A61P35/00 ; A61P33/00 ; A61K31/53 ; A61P21/00
Abstract:
The present invention provides small-molecule inhibitors of BMP signaling and compositions and methods for inhibiting BMP signaling. These compounds and compositions may be used to modulate cell growth, differentiation, proliferation, and apoptosis, and thus may be useful for treating diseases or conditions associated with BMP signaling, including inflammation, cardiovascular disease, hematological disease, cancer, and bone disorders, as well as for modulating cellular differentiation and/or proliferation. These compounds and compositions may also be used to reduce circulating levels of ApoB-100 or LDL and treat or prevent acquired or congenital hypercholesterolemia or hyperlipoproteinemia; diseases, disorders, or syndromes associated with defects in lipid absorption or metabolism; or diseases, disorders, or syndromes caused by hyperlipidemia.
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