Invention Application
- Patent Title: TRIFLUORMETHYLOXAZINE AMIDINES AS BACE1 INHIBITORS
- Patent Title (中): 三氟甲基嘧啶作为BACE1抑制剂
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Application No.: PCT/EP2015/066505Application Date: 2015-07-20
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Publication No.: WO2016012384A1Publication Date: 2016-01-28
- Inventor: DOLENTE, Cosimo , BARTELS, Bjoern , GUBA, Wolfgang , HAAP, Wolfgang , OBST SANDER, Ulrike , PETERS, Jens-Uwe , ROGERS-EVANS, Mark , WOLTERING, Thomas
- Applicant: F. HOFFMANN-LA ROCHE AG , HOFFMANN-LA ROCHE INC. , SIENA BIOTECH S.P.A.
- Applicant Address: Grenzacherstrasse 124 CH-4070 Basel CH
- Assignee: F. HOFFMANN-LA ROCHE AG,HOFFMANN-LA ROCHE INC.,SIENA BIOTECH S.P.A.
- Current Assignee: F. HOFFMANN-LA ROCHE AG,HOFFMANN-LA ROCHE INC.,SIENA BIOTECH S.P.A.
- Current Assignee Address: Grenzacherstrasse 124 CH-4070 Basel CH
- Agency: MUELLER-AFRAZ, Simona
- Priority: EP14178088.2 20140722
- Main IPC: C07D413/14
- IPC: C07D413/14 ; A61K31/5355 ; A61P25/28
Abstract:
The present invention provides a compound of formula I having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.
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