Invention Application
- Patent Title: METHODS AND MATERIALS FOR PRODUCING 6-CARBON MONOMERS
- Patent Title (中): 生产六碳单体的方法和材料
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Application No.: PCT/US2015/060747Application Date: 2015-11-13
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Publication No.: WO2016077800A1Publication Date: 2016-05-19
- Inventor: BOTES, Adriana, Leonora , CONRADIE, Alex Van Eck , KADI, Nadia
- Applicant: INVISTA NORTH AMERICA S.Á.R.L. , INVISTA TECHNOLOGIES S.A R.L.
- Applicant Address: Three Little Falls Centre 2801 Centerville Road Wilmington, Delaware 19808 US
- Assignee: INVISTA NORTH AMERICA S.Á.R.L.,INVISTA TECHNOLOGIES S.A R.L.
- Current Assignee: INVISTA NORTH AMERICA S.Á.R.L.,INVISTA TECHNOLOGIES S.A R.L.
- Current Assignee Address: Three Little Falls Centre 2801 Centerville Road Wilmington, Delaware 19808 US
- Agency: MOUTA, Carla et al.
- Priority: US62/079,903 20141114; US62/255,276 20151113
- Main IPC: C12P7/42
- IPC: C12P7/42 ; C12P13/00 ; C12P7/18 ; C12P7/44 ; C12P17/10 ; C12N9/10
Abstract:
This document describes biochemical pathways for producing 6-hydroxyhexanoic acid using a polypeptide having ß-ketothiolase activity to form a 3-oxo-6-hydroxyhexanoyl-CoA intermediate. 6-hydroxyhexanoic acid can be enzymatically converted to adipic acid, caprolactam, 6-aminohexanoic acid, hexamethylenediamine or 1,6-hexanediol. This document also describes recombinant hosts producing 6-hydroxyhexanoic acid as well as adipic acid, caprolactam, 6-aminohexanoic acid, hexamethylenediamine and 1,6-hexanediol.
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