A ground fault isolation system (100) and ground fault isolation circuit for isolating ground faults in electrical subsea conductor lines. The system includes a main power hub, a plurality of digital controllers operatively connected to the main power hub via electrical subsea conductor lines, and a ground fault isolation circuit (100). The ground fault isolation circuit includes a plurality of loads connected to a ground fault detection circuit (12), each load including one relay (22) on the positive power bus (18) and one relay (26) on the negative power bus (20). The ground fault detection circuit is connected to a DC to DC isolation circuit (10) that prevents a main power bus ground fault in the event of a ground fault on one of the loads. The relays are connected to a digital controller (16) on the other end, which isolates a load when a ground fault is detected, but powers the remaining unaffected loads.