A method of driving an active matrix electro-wetting on dielectric (AM-EWOD) device comprises (i) setting a reference electrode to a first reference voltage; (ii) writing a set of data to array element electrodes of array elements of the device; and (iii) either (a) maintaining the voltages written to the array element electrodes until a time t 0 or (b) re-writing the set of data N-1 times (where N ≧ 2). The reference electrode is then set to a second reference voltage different from the first reference voltage, and features (i) to (iii) are repeated. When the data are first written, there is a delay between the time when the voltage on the reference electrode is transitioned and the time when a given array element is next written with data. Feature (iii) allows the time for which the correct data values are held to be increased relative to the time for which incorrect data values may possibly be held, so that the time for which an element may be in an incorrect state can be made insignificant in terms of its effect on unwantedly perturbing droplet operations.