Invention Application
WO2016142886A2 3-SUBSTITUTED-1,2,4-OXADIAZOLE AND THIADIAZOLE COMPOUNDS AS IMMUNOMODULATORS
审中-公开
作为免疫调节剂的3-取代-1,2,4-氧杂噻唑和噻唑化合物
- Patent Title: 3-SUBSTITUTED-1,2,4-OXADIAZOLE AND THIADIAZOLE COMPOUNDS AS IMMUNOMODULATORS
- Patent Title (中): 作为免疫调节剂的3-取代-1,2,4-氧杂噻唑和噻唑化合物
-
Application No.: PCT/IB2016/051343Application Date: 2016-03-09
-
Publication No.: WO2016142886A2Publication Date: 2016-09-15
- Inventor: SASIKUMAR, Pottayil Govindan Nair , RAMACHANDRA, Muralidhara , PRASAD, Appukkuttan , NAREMADDEPALLI, Seetharamaiah Setty Sudarshan
- Applicant: AURIGENE DISCOVERY TECHNOLOGIES LIMITED
- Applicant Address: 39-40, KIADB Industrial Area Electronic City Phase II, Hosur Road Karnataka Bangalore 560100 IN
- Assignee: AURIGENE DISCOVERY TECHNOLOGIES LIMITED
- Current Assignee: AURIGENE DISCOVERY TECHNOLOGIES LIMITED
- Current Assignee Address: 39-40, KIADB Industrial Area Electronic City Phase II, Hosur Road Karnataka Bangalore 560100 IN
- Priority: IN1174/CHE/2015 20150310; IN1176/CHE/2015 20150310
- Main IPC: A61K31/00
- IPC: A61K31/00
Abstract:
The present invention relates to 3-substituted-1,2,4-oxadiazole and thiadiazole compounds of formula (I) or formula (II) and their use to inhibit the programmed cell death 1 (PD-1) signaling pathway and/or for treatment of disorders by inhibiting an immunosuppressive signal induced by PD-1, PD-L1 or PD-L2.
Information query
