A computer-implemented method for generating a longitudinal data profile from multiple disparate data sources is provided. The method includes storing, at a central data hub, first de-identified data received from a first data source, the first de-identified data including a plurality of data records having encrypted identifying data and an anonymous ID assigned to each record, wherein the anonymous ID is assigned based on a master list that includes a list of identifiers and corresponding anonymous IDs for each identifier. The method further includes storing second de-identified data received from a second data source, and storing third de-identified data received from a third data source. The method further includes processing the first, second, and third de-identified data to link the first, second, and third de-identified data using the anonymous ID, and generating the longitudinal data profile from the linked first, second, and third de-identified data.