Invention Application
WO2016181228A2 SYSTEMS AND METHODS FOR GROWING A BIOFILM OF PROBIOTIC BACTERIA ON SOLID PARTICLES FOR COLONIZATION OF BACTERIA IN THE GUT
审中-公开
用于生长细菌生物细菌生物体的系统和方法，用于在细菌中菌落细菌的固体颗粒
- Patent Title: SYSTEMS AND METHODS FOR GROWING A BIOFILM OF PROBIOTIC BACTERIA ON SOLID PARTICLES FOR COLONIZATION OF BACTERIA IN THE GUT
- Patent Title (中): 用于生长细菌生物细菌生物体的系统和方法，用于在细菌中菌落细菌的固体颗粒
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Application No.: PCT/IB2016/000933Application Date: 2016-05-09
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Publication No.: WO2016181228A2Publication Date: 2016-11-17
- Inventor: BARAM, David , DIAMANT, Rachel , DABOUSH, David
- Applicant: MYBIOTIX PHARMA LTD.
- Applicant Address: 5 Golda Meir Blvd., 5th Floor Science Park POB 4061 7414001 Ness-Ziona IL
- Assignee: MYBIOTIX PHARMA LTD.
- Current Assignee: MYBIOTIX PHARMA LTD.
- Current Assignee Address: 5 Golda Meir Blvd., 5th Floor Science Park POB 4061 7414001 Ness-Ziona IL
- Priority: US62/159,849 20150511; US62/159,846 20150511
- Main IPC: C12N1/20
- IPC: C12N1/20
Abstract:
The present invention provides a method, wherein the method forms a biofilm, wherein the biofilm comprises a population of at least one bacterial strain attached to particles, wherein the biofilm is configured to colonize a gut of a subject in need thereof for at least five days, when ingested by the subject, the method comprising: a. obtaining a population comprising at least one strain of bacteria; b. inoculating a growth medium containing particles with the population comprising at least one strain of bacteria; c. incubating the particles with the population comprising at least one bacterial strain for a time sufficient for the population of at least one strain of bacteria to attach to the particles; and d. culturing the population comprising at least one strain of bacteria attached to the particles in a growth medium, for a time sufficient to form a biofilm.
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