Invention Application
WO2016191698A1 PENTOSAN POLYSULFATE SODIUM FOR THE TREATMENT OF SICKLE CELL DISEASE
审中-公开
PENTOSAN POLYSULFATE SODIUM FOR THE TREATMENT SICKLE CELL DISEASE
- Patent Title: PENTOSAN POLYSULFATE SODIUM FOR THE TREATMENT OF SICKLE CELL DISEASE
- Patent Title (中): PENTOSAN POLYSULFATE SODIUM FOR THE TREATMENT SICKLE CELL DISEASE
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Application No.: PCT/US2016/034691Application Date: 2016-05-27
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Publication No.: WO2016191698A1Publication Date: 2016-12-01
- Inventor: EMBURY, Stephen, H.
- Applicant: VANGUARD THERAPEUTICS, INC.
- Applicant Address: 108 Eagle Trace Drive Half Moon Bay, CA 94019 US
- Assignee: VANGUARD THERAPEUTICS, INC.
- Current Assignee: VANGUARD THERAPEUTICS, INC.
- Current Assignee Address: 108 Eagle Trace Drive Half Moon Bay, CA 94019 US
- Agency: SHIEH-NEWTON, Terri et al.
- Priority: US62/245,766 20151023; US62/166,863 20150527
- Main IPC: A61P7/00
- IPC: A61P7/00 ; A61K31/737 ; A61K31/715
Abstract:
This invention is directed to, inter alia , compositions comprised of pentosan polysulfate sodium (PPS) components and methods for making such compositions and using the same for the treatment of sickle cell disease (SCD). The disclosed compositions possess superior bioavailability as well as P-selectin blocking activity for the treatment of sickle-cell disease (SCD). Methods for using the same are additionally provided herein. Also provided herein is a method for detecting or quantifying PPS or a PPS fraction in solutions or in a biological sample obtained from an animal or an individual.
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