发明申请
- 专利标题： METHOD FOR PRODUCING FLUTEMETAMOL
- 专利标题（中）： 制备氟苯咪胺的方法
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申请号： PCT/EP2016/074840申请日： 2016-10-17
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公开(公告)号： WO2017071980A1公开(公告)日： 2017-05-04
- 发明人: OKUMURA, Yuki , TONOYA, Gota , MATSUNAMI, Tomoyuki
- 申请人： GE HEALTHCARE LIMITED , NIHON MEDI-PHYSICS CO., LTD
- 申请人地址： Amersham Place Little Chalfont Buckinghamshire HP7 9NA GB
- 专利权人： GE HEALTHCARE LIMITED,NIHON MEDI-PHYSICS CO., LTD
- 当前专利权人： GE HEALTHCARE LIMITED,NIHON MEDI-PHYSICS CO., LTD
- 当前专利权人地址： Amersham Place Little Chalfont Buckinghamshire HP7 9NA GB
- 代理机构： ALDENBÄCK, Ulla et al.
- 优先权： JP2015-211413 20151028
- 主分类号： C07D277/66
- IPC分类号： C07D277/66
摘要：
Provided is a method for producing flutemetamol including the steps of: reacting a precursor compound represented by a predetermined general formula with a radioactive fluoride to obtain a 18 F labeling compound represented by a predetermined general formula;allowing a strong base to act on the reaction mixture of the above step containing the precursor compound and the 18 F labeling compound;after the above step, purifying the 18 F labeling compound using a reverse phase solid phase extraction cartridge;and removing a protective group to obtain [ 18 F] flutemetamol.
