发明申请
- 专利标题： COMPOSITIONS AND METHODS RELATING TO TUMOR ANALYSIS
- 专利标题（中）： 与肿瘤分析相关的组合物和方法
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申请号： PCT/US2016/059711申请日： 2016-10-31
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公开(公告)号： WO2017075585A1公开(公告)日： 2017-05-04
- 发明人: WILES, Michael, V. , HOSUR, Vishnu , SHULTZ, Leonard, D.
- 申请人： THE JACKSON LABORATORY
- 申请人地址： 610 Main Street Bar Harbor, ME 04609 US
- 专利权人： THE JACKSON LABORATORY
- 当前专利权人： THE JACKSON LABORATORY
- 当前专利权人地址： 610 Main Street Bar Harbor, ME 04609 US
- 代理机构： STAPLE, Julie, K, et al.
- 优先权： US62/248,417 20151030
- 主分类号： A01K67/027
- IPC分类号： A01K67/027 ; C12N9/64 ; G01N33/50 ; A61K49/00
摘要：
A genetically modified NOD.Cg -Prkdc scid Il2rg tm1Wjl /Sz J mouse is provided by the present invention wherein the genome of the mouse includes a mutated Rhbdf2 gene such that the mouse expresses a mutant iRhom2 protein, wherein the mutant iRhom2 protein differs from wild-type iRhom2 protein due to one or more mutations selected from p.I156T, p.D158N and p.P159L, and wherein the mouse is characterized by hairless phenotype and increased growth of an exogenous tumor compared to a mouse of the same genetic background which express wild-type iRhom2 protein.
