Invention Application
WO2017100642A1 METHODS FOR REDUCING OR PREVENTING GROWTH OF TUMORS RESISTANT TO EGFR AND/OR ERBB3 BLOCKADE
审中-公开
减少或预防抗EGFR和/或ERBB3阻断肿瘤生长的方法
- Patent Title: METHODS FOR REDUCING OR PREVENTING GROWTH OF TUMORS RESISTANT TO EGFR AND/OR ERBB3 BLOCKADE
- Patent Title (中): 减少或预防抗EGFR和/或ERBB3阻断肿瘤生长的方法
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Application No.: PCT/US2016/065925Application Date: 2016-12-09
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Publication No.: WO2017100642A1Publication Date: 2017-06-15
- Inventor: DALY, Christopher , CASTANARO, Carla , ZHANG, Wen , THURSTON, Gavin
- Applicant: REGENERON PHARMACEUTICALS, INC.
- Applicant Address: 777 Old Saw Mill River Road Tarrytown, New York 10591-6707 US
- Assignee: REGENERON PHARMACEUTICALS, INC.
- Current Assignee: REGENERON PHARMACEUTICALS, INC.
- Current Assignee Address: 777 Old Saw Mill River Road Tarrytown, New York 10591-6707 US
- Agency: TERMES, Lance A. et al.
- Priority: US62/266,103 20151211
- Main IPC: C07K16/28
- IPC: C07K16/28 ; C07K16/32 ; A61P35/00 ; A61K31/00
Abstract:
The present invention provides methods for inhibiting or attenuating the growth of a tumor that is resistant to a blockade of EGFR, which include administering an EGFR inhibitor, an EGFR inhibitor and a FGFR inhibitor, or an EGFR inhibitor, an FGFR inhibitor and an ErbB3 inhibitor to a subject having a tumor that is or may become resistant to the blockade of EGFR. Blockade of EGFR, FGFR and/or ErbB3 may be effectuated using target specific antibodies or fragments thereof, small molecule tyrosine kinase inhibitors or a combination thereof.
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