发明申请
WO2017147597A1 PEPTIDE VACCINES COMPRISING SELF-ASSEMBLING POLYMER NANOPARTICLES
审中-公开
包含自组装聚合物纳米颗粒的肽疫苗
- 专利标题： PEPTIDE VACCINES COMPRISING SELF-ASSEMBLING POLYMER NANOPARTICLES
- 专利标题（中）： 包含自组装聚合物纳米颗粒的肽疫苗
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申请号： PCT/US2017/019748申请日： 2017-02-27
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公开(公告)号： WO2017147597A1公开(公告)日： 2017-08-31
- 发明人: SEDER, Robert , LYNN, Geoffrey
- 申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
- 申请人地址： National Institutes of Health Office of Technology Transfer 6011 Executive Boulevard, Suite 325, MSC 7660 Bethesda, MD 20852-7660 US
- 专利权人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
- 当前专利权人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
- 当前专利权人地址： National Institutes of Health Office of Technology Transfer 6011 Executive Boulevard, Suite 325, MSC 7660 Bethesda, MD 20852-7660 US
- 代理机构： SCOTT, Gregory, K.
- 优先权： US62/300,822 20160227
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; A61K39/39
摘要：
Embodiments of a novel platform for delivering a peptide antigen to a subject to induce an immune response to the peptide antigen are provided. For example, nanoparticle polyplexes are provided that comprise a polymer linked to a peptide conjugate by an electrostatic interaction. The conjugate comprises a peptide antigen linked to a peptide tag through an optional linker. An adjuvant may be included in the nanoparticle polyplex, linked to either the polymer or the conjugate, or admixed with the nanoparticles. The nanoparticle polyplex can be administered to a subject to induce an immune response to the peptide antigen.
