Invention Application
- Patent Title: NUCLEIC ACID CONSTRUCTS AND VECTORS FOR ONCOSELECTIVE EXPRESSION OF A TRANSGENE
- Patent Title (中): 转录后反义表达的核酸构建体和载体
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Application No.: PCT/EP2017/055836Application Date: 2017-03-13
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Publication No.: WO2017153606A1Publication Date: 2017-09-14
- Inventor: MÉNDEZ DE LA IGLESIA, Raúl , FILLAT FONTS, Cristina , VILLANUEVA VERDEJO, Eneko
- Applicant: FUNDACIÓ INSTITUT DE RECERCA BIOMÈDICA (IRB BARCELONA) , INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS , INSTITUT D’INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER (IDIBAPS)
- Applicant Address: Baldiri Reixac, 10 E-08028 Barcelona ES
- Assignee: FUNDACIÓ INSTITUT DE RECERCA BIOMÈDICA (IRB BARCELONA),INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS,INSTITUT D’INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER (IDIBAPS)
- Current Assignee: FUNDACIÓ INSTITUT DE RECERCA BIOMÈDICA (IRB BARCELONA),INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS,INSTITUT D’INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER (IDIBAPS)
- Current Assignee Address: Baldiri Reixac, 10 E-08028 Barcelona ES
- Agency: ALCONADA RODRIGUEZ, Agustín
- Priority: EP16382108.5 20160311
- Main IPC: A61K35/761
- IPC: A61K35/761 ; C12N15/85 ; C12N15/86
Abstract:
The invention relates to a nucleic acid construct comprising polynucleotide of interest and an untranslated 3' sequence including at least two cytoplasmic polyadenylation elements. The invention also relates to vectors, viral particles, cells and pharmaceutical compositions comprising said nucleic acid construct, and to their use for inducing selective expression of a polynucleotide in a tumor cell, and said nucleic acid construct for use in medicine and in the treatment of cancer.
Information query
