Invention Application
WO2018005812A1 DIPROVOCIMS: A NEW AND POTENT CLASS OF TLR AGONISTS
审中-公开
DIPROVOCIMS：一种全新而有力的TLR激进分子
- Patent Title: DIPROVOCIMS: A NEW AND POTENT CLASS OF TLR AGONISTS
- Patent Title (中): DIPROVOCIMS：一种全新而有力的TLR激进分子
-
Application No.: PCT/US2017/040028Application Date: 2017-06-29
-
Publication No.: WO2018005812A1Publication Date: 2018-01-04
- Inventor: BEUTLER, Bruce , BOGER, Dale, L.
- Applicant: THE SCRIPPS RESEARCH INSTITUTE , THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM , BEUTLER, Bruce , BOGER, Dale, L.
- Applicant Address: 10550 North Torrey Pines Road La Jolla, CA 92037 US
- Assignee: THE SCRIPPS RESEARCH INSTITUTE,THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM,BEUTLER, Bruce,BOGER, Dale, L.
- Current Assignee: THE SCRIPPS RESEARCH INSTITUTE,THE BOARD OF REGENTS OF THE UNIVERSITY OF TEXAS SYSTEM,BEUTLER, Bruce,BOGER, Dale, L.
- Current Assignee Address: 10550 North Torrey Pines Road La Jolla, CA 92037 US
- Agency: GAMSON, Edward, P. et al.
- Priority: US62/356,314 20160629
- Main IPC: C07D403/10
- IPC: C07D403/10 ; A61K31/40 ; A61K31/4025
Abstract:
A diprovocim compound that corresponds in structure to structural Formula V is disclosed, wherein A, W, Z, R 1 , R 2 , R 3 and R 4 (when present) are defined within. A diprovocim compound has immune-adjuvant properties on human and mouse cells in culture and on in vivo immunization of mice. A composition containing a diprovocim and a method of using a compound are also disclosed. The immunostimulatory activity of a diprovocim compound is similar to that of LPS, to which there is no apparent structural similarity. A contemplated compound bears no structural similarity to either the TLR1/TLR2 lipoprotein agonists nor to any other synthetic TLR agonist, and is remarkably easy to prepare and synthetically modify.
Information query
