Invention Application
WO2018045210A1 METHOD OF TREATING LOCALIZED FIBROTIC DISORDERS USING AN IL-33/TNF BISPECIFIC ANTIBODY
审中-公开
使用IL-33 / TNF双特异性抗体治疗局限性纤维性疾病的方法
- Patent Title: METHOD OF TREATING LOCALIZED FIBROTIC DISORDERS USING AN IL-33/TNF BISPECIFIC ANTIBODY
- Patent Title (中): 使用IL-33 / TNF双特异性抗体治疗局限性纤维性疾病的方法
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Application No.: PCT/US2017/049691Application Date: 2017-08-31
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Publication No.: WO2018045210A1Publication Date: 2018-03-08
- Inventor: 180 THERAPEUTICS LP , NANCHAHAL, Jagdeep , LARSEN, Glenn, R. , FELDMANN, Marc
- Applicant: 180 THERAPEUTICS LP , NANCHAHAL, Jagdeep , LARSEN, Glenn, R. , FELDMANN, Marc
- Applicant Address: One Broadway, 14th Floor Cambridge, MA US
- Assignee: 180 THERAPEUTICS LP,NANCHAHAL, Jagdeep,LARSEN, Glenn, R.,FELDMANN, Marc
- Current Assignee: 180 THERAPEUTICS LP,NANCHAHAL, Jagdeep,LARSEN, Glenn, R.,FELDMANN, Marc
- Current Assignee Address: One Broadway, 14th Floor Cambridge, MA US
- Agency: WHITE, John, P.
- Priority: US62/383,246 20160902
- Main IPC: A61K38/02
- IPC: A61K38/02 ; A61K39/395 ; C07K16/24 ; C07K16/46 ; C07K14/715
Abstract:
The subject invention provides a method of treating a patient suffering from a localized fibrotic condition which comprises administering to the patient an amount of an IL-33 antagonist effective to treat the patient. The invention also provides a method of treating a patient suffering from a localized fibrotic condition which comprises administering to the patient an amount of a bispecific antibody comprising an IL-33 antigen binding domain of which (i) binds to and inhibits activation of, an IL-33 receptor, or (ii) specifically binds to IL-33 and inhibits IL-33 from binding to the IL-33 receptor, and a TNF antigen binding domain of which (i) binds to and inhibits activation of, a TNF receptor, or (ii) specifically binds to TNF and inhibits TNF from binding to the TNF receptor, wherein the bispecific antibody is effective to treat the patient.
Information query
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