Invention Application
WO2018065085A1 COATING OF NANOPARTICLE SURFACES WITH CYCLOPEPTIDES FOR IMPROVING DELIVERY OF AGENTS VIA THE ORAL ROUTE
审中-公开
具有环肽的纳米颗粒表面涂层用于改善通过口服途径给药的作用
- Patent Title: COATING OF NANOPARTICLE SURFACES WITH CYCLOPEPTIDES FOR IMPROVING DELIVERY OF AGENTS VIA THE ORAL ROUTE
- Patent Title (中): 具有环肽的纳米颗粒表面涂层用于改善通过口服途径给药的作用
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Application No.: PCT/EP2017/001119Application Date: 2017-09-19
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Publication No.: WO2018065085A1Publication Date: 2018-04-12
- Inventor: UHL, Philipp , MIER, Walter , HABERKORN, Uwe , SAUTER, Max
- Applicant: RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG
- Applicant Address: Grabengasse 1 69117 Heidelberg DE
- Assignee: RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG
- Current Assignee: RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG
- Current Assignee Address: Grabengasse 1 69117 Heidelberg DE
- Agency: LENHARD, Konstanze
- Priority: EP16002139.0 20161005
- Main IPC: A61K9/00
- IPC: A61K9/00 ; A61K9/19 ; A61K9/51
Abstract:
The present invention relates to a surface-coated nanoparticle comprising biodegradable polymer chains and cyclopeptides, wherein the cyclopeptides are covalently attached to the biodegradable polymer chains forming the nanoparticle, thereby coating the surface of the nanoparticle. The present invention further relates to the use of said surface-coated nanoparticle as a capsule for an agent for improving the oral delivery thereof. In another aspect, the present invention relates to the surface-coated nanoparticle for use in the treatment or prevention of a disorder or disease in a patient, wherein the treatment or prevention is achieved by mucosal uptake of the surface-coated nanoparticle via the oral route.
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