发明申请
- 专利标题： PIPERIDINE DERIVATIVES AS LIVER X RECEPTOR BETA AGONISTS, COMPOSITIONS, AND THEIR USE
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申请号： PCT/US2017/055688申请日： 2017-10-09
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公开(公告)号： WO2018071315A3公开(公告)日： 2018-04-19
- 发明人: RUDD, Michael, T. , MENG, Zhaoyang , WAI, Jenny , BENNETT, David Jonathan , BRNARDIC, Edward, J. , LIVERTON, Nigel, J. , STACHEL, Shawn, J. , HAN, Yongxin , TEMPEST, Paul , ZHU, Jiuxiang , XU, Xuewang , ZHU, Bin , HUANG, Chuanman
- 申请人： MERCK SHARP & DOHME CORP. , RUDD, Michael, T. , MENG, Zhaoyang , WAI, Jenny , BENNETT, David Jonathan , BRNARDIC, Edward, J. , LIVERTON, Nigel, J. , STACHEL, Shawn, J. , HAN, Yongxin , TEMPEST, Paul , ZHU, Jiuxiang , XU, Xuewang , ZHU, Bin , HUANG, Chuanman
- 申请人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 US
- 专利权人： MERCK SHARP & DOHME CORP.,RUDD, Michael, T.,MENG, Zhaoyang,WAI, Jenny,BENNETT, David Jonathan,BRNARDIC, Edward, J.,LIVERTON, Nigel, J.,STACHEL, Shawn, J.,HAN, Yongxin,TEMPEST, Paul,ZHU, Jiuxiang,XU, Xuewang,ZHU, Bin,HUANG, Chuanman
- 当前专利权人： MERCK SHARP & DOHME CORP.,RUDD, Michael, T.,MENG, Zhaoyang,WAI, Jenny,BENNETT, David Jonathan,BRNARDIC, Edward, J.,LIVERTON, Nigel, J.,STACHEL, Shawn, J.,HAN, Yongxin,TEMPEST, Paul,ZHU, Jiuxiang,XU, Xuewang,ZHU, Bin,HUANG, Chuanman
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 US
- 代理机构： MERCK SHARP & DOHME CORP.
- 优先权： CNPCT/CN2016/102097 20161014
- 主分类号： C07D239/02
- IPC分类号： C07D239/02 ; C07F9/02 ; C07D239/42
摘要：
In its many embodiments, the present invention provides certain piperidine compounds of the Formula (I): and pharmaceutically acceptable salts thereof, wherein X, Y, R 1 , R 2 , R 3 , L, R 4 , L 1 ,Q, and R 5 are as defined herein. The novel compounds of the invention, and pharmaceutically acceptable compositions comprising a compound thereof, are useful as Liver Χ-β receptor (LXRβ) agonists, and may be useful for treating or preventing pathologies related thereto. Such pathologies include, but are not limited to, inflammatory diseases and diseases characterized by defects in cholesterol and lipid metabolism, such as Alzheimer's disease.
公开/授权文献
