Invention Application
- Patent Title: LIPOFULLERENE-SACCHARIDE CONJUGATES AND THEIR USE AS ANTIMETASTATIC AGENTS FOR THE INHIBITION OF MAMMALIAN NEOPLASMS
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Application No.: PCT/US2018/019463Application Date: 2018-02-23
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Publication No.: WO2018156923A1Publication Date: 2018-08-30
- Inventor: MITCHELL, Ian , SUBBIAH, Ayyappan , BENSIMON, Daniel David
- Applicant: LIVEPET, LLC
- Applicant Address: 7028 Cielo Azul Pass Austin, Texas 78732 US
- Assignee: LIVEPET, LLC
- Current Assignee: LIVEPET, LLC
- Current Assignee Address: 7028 Cielo Azul Pass Austin, Texas 78732 US
- Agency: PERSKY, Neal E.
- Priority: US62/462,870 20170223
- Main IPC: A61K31/138
- IPC: A61K31/138 ; A61K31/337 ; A61K31/4745
Abstract:
some embodiments, a lipofullerene-saccharide compound and a method of inhibiting and/or ameliorating metastasis of neoplastic cells using said compound is disclosed herein. The lipofullerene-saccharide compound may be used in therapeutically effective doses to inhibit the metastasis of neoplasms in mammals. some embodiments, the method may include administering to a subject an effective amount of a pharmaceutically acceptable formulation including a lipofullerene-saccharide compound. In some embodiments, the lipofullerene-saccharide compound may be formed by reacting (e.g., coupling) a lipid and a saccharide with a fullerene. some embodiments, neoplastic cells may include pancreatic cancer cells, prostate cancer cells, lung cancer cells, breast cancer cells, colon cancer cells, and/or brain cancer cells. A significant anti-metastatic effect has been observed on a metastatic nude-mouse model of human pancreatic cancer BxPC-3 cell lines constructed orthotopically as a result of therapeutic treatment with the lipofullerene-saccharide conjugate.
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