Invention Application
- Patent Title: COMPOSITION COMPRISING A SPECIFIC p38α INHIBITOR AND AN AGENT THAT INDUCES CHROMOSOME INSTABILITY AND MEDICAL USES THEREOF
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Application No.: PCT/EP2018/065519Application Date: 2018-06-12
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Publication No.: WO2018229057A1Publication Date: 2018-12-20
- Inventor: RODRIGUEZ NEBREDA, Ángel , IGEA FERNÁNDEZ, Ana , CÁNOVAS BILBAO, Begoña
- Applicant: FUNDACIÓ INSTITUT DE RECERCA BIOMÈDICA (IRB BARCELONA) , INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS
- Applicant Address: Baldiri Reixac, 10 E-08028 Barcelona ES
- Assignee: FUNDACIÓ INSTITUT DE RECERCA BIOMÈDICA (IRB BARCELONA),INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS
- Current Assignee: FUNDACIÓ INSTITUT DE RECERCA BIOMÈDICA (IRB BARCELONA),INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS
- Current Assignee Address: Baldiri Reixac, 10 E-08028 Barcelona ES
- Agency: ALCONADA RODRIGUEZ, Agustín
- Priority: EP17382360.0 20170612
- Main IPC: A61K45/06
- IPC: A61K45/06 ; A61K31/337 ; A61K31/437 ; A61K31/4418 ; A61K31/4745 ; A61K31/7048 ; G01N33/574 ; A61P35/00
Abstract:
The present invention relates to compositions comprising a specific p38α inhibitor and an agent that induces chromosome instability, wherein the specific p38α inhibitor has a half maximal inhibitory concentration (IC50) equal to or less than 40 nM. The invention also relates to the above compositions or to a specific p38α inhibitor for use in the treatment of breast cancer, wherein the breast cancer is characterised by a high degree of aneuploidy. Finally, the invention relates to a method for identifying a breast cancer patient who responds to a treatment with the above compositions or with a specific p38α inhibitor, wherein the breast cancer is characterised by a high degree of aneuploidy, and a method for selecting a treatment for a breast cancer patient.
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