Embodiments of systems, apparatuses, and methods for vector-packed fractional multiplication of signed words with rounding, saturation, and high-result selection in a processor are described. For example, execution circuitry executes a decoded instruction to perform a fractional multiplication operation for each of a plurality of pairs of packed data elements to yield a plurality of output values, round each of the plurality of output values, detect whether any of the plurality of output values reflect an overflow or underflow, for any of the plurality of output values that reflect an overflow or underflow, saturate the output value, and store the plurality of output values into a corresponding plurality of positions of the packed data destination operand.