- 专利标题： TREATMENT OF HEART DISEASE BY INHIBITION OF THE ACTION OF MUSCLE A-KINASE ANCHORING PROTEIN (MAKAP)
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申请号： PCT/US2018/040913申请日： 2018-07-05
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公开(公告)号： WO2019010301A8公开(公告)日： 2019-01-10
- 发明人: KAPILOFF, Michael S.
- 申请人： KAPILOFF, Michael S.
- 申请人地址： 24133 Young Court Los Altos, California 94024 US
- 专利权人： KAPILOFF, Michael S.
- 当前专利权人： KAPILOFF, Michael S.
- 当前专利权人地址： 24133 Young Court Los Altos, California 94024 US
- 代理机构： CRANE, Sharon E.
- 优先权： US62/529,224 20170706
- 主分类号： A61K31/713
- IPC分类号： A61K31/713 ; A61K38/45 ; A61K48/00 ; A61P9/00 ; A61P9/10 ; C07K14/075
摘要：
The present invention provides a method of protecting the heart from damage, by administering to a patient at risk of such damage, a pharmaceutically effective amount of a composition which inhibits the interaction of RSK3 and mAKAPβ, or the expression or activity of one or both of those molecules. This composition is preferably in the form of an siRNA construct, more preferably an shRNA construct, which inhibits the expression of mAKAPβ.
公开/授权文献
