A suturing device include a handle, an elongate body, an actuator, and a needle holder. The elongate body connects with the handle. The actuator interacts with the elongate body and is operable between a first operating position and a second operating position. The actuator includes a manually operated member including an operator contact surface. The needle holder extends away from a distal end portion or is provided as part of the distal end portion of the elongate body. The needle holder includes a distal end section having a distal-most tip and defining a needle passage and a distal opening adjacent the distal-most tip. The needle passage is configured to receive at least a portion of an associated needle when the actuator is in the first operating position. The needle holder and the elongate body are rotatable with respect to the handle about a rotational axis.