- 专利标题： COMBINATION OF ANTI-IL10 AND ANTI-PD1 ANTIBODIES IN CANCER TREATMENT
-
申请号： PCT/EP2018/076114申请日： 2018-09-26
-
公开(公告)号： WO2019072566A1公开(公告)日： 2019-04-18
- 发明人: UHEREK, Christoph , KOENIG, Martin , LEMKE, Sylvia , HUEBER, Christian , HERBENER, Peter , WOLLERSHEIM, Alexandra
- 申请人： BIOTEST AG
- 申请人地址： Landsteinerstr. 5 63303 Dreieich DE
- 专利权人： BIOTEST AG
- 当前专利权人： BIOTEST AG
- 当前专利权人地址： Landsteinerstr. 5 63303 Dreieich DE
- 代理机构： WICHMANN, Hendrik
- 优先权： EP17195652.7 20171010; EP18168742.7 20180423
- 主分类号： C07K16/24
- IPC分类号： C07K16/24 ; C07K16/28 ; A61K39/00
摘要：
The present disclosure relates to the field of oncology, more particularly to immune oncology combination therapies for use in the treatment of malignant melanoma. In particular, the present invention relates to an interleukin 10 (IL-10) neutralizing antibody or fragment thereof for use in combination with a PD-1 inhibitor in the treatment of melanoma in a mammal, in particular in a human. Further provided is an interleukin 10 (IL-10) neutralizing antibody or fragment thereof for use in the treatment of melanoma in a mammal which is undergoing treatment with a PD-1 inhibitor. Similarly, the present disclosure further relates to a PD-1 inhibitor for use in combination with an interleukin 10 (IL-10) neutralizing antibody or fragment thereof in the treatment of melanoma in a mammal. Further disclosed is a PD-1 inhibitor for use in the treatment of melanoma in a mammal who is undergoing treatment with an interleukin 10 (IL-10) neutralizing antibody or fragment thereof.
