- 专利标题: DIAGNOSING DISEASE VIA GENE EXPRESSION PROFILE IN SYNCHRONIZED CELLS
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申请号: PCT/US2018/064180申请日: 2018-12-06
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公开(公告)号: WO2019113277A1公开(公告)日: 2019-06-13
- 发明人: CHIRILA, Florin Valentin , ALKON, Daniel L.
- 申请人: NEURODIAGNOSTICS LLC
- 申请人地址: 9601 Medical Drive, Suite 3 Rockville, MD 20850 US
- 专利权人: NEURODIAGNOSTICS LLC
- 当前专利权人: NEURODIAGNOSTICS LLC
- 当前专利权人地址: 9601 Medical Drive, Suite 3 Rockville, MD 20850 US
- 代理机构: MORRISON, Alan J.
- 优先权: US62/596,613 20171208
- 主分类号: G01N33/50
- IPC分类号: G01N33/50 ; G01N33/68 ; C12Q1/6883
摘要:
This invention provides a method for determining whether a human subject is afflicted with a predetermined disorder comprising the steps of (a) synchronizing a population of suitable cells derived from the subject; and (b) in the resulting synchronized cell population, measuring the expression level of a gene known to be differentially expressed between corresponding synchronized cells derived from patients afflicted with the disorder and those derived from non-afflicted patients, whereby the subject is afflicted with the disorder if the expression level measured in step (b) is consistent with that gene's expression level in corresponding synchronized cells derived from patients afflicted with the disorder, and the subject is not afflicted with the disorder if the expression level measured in step (b) is consistent with that gene's expression level in corresponding synchronized cells derived from non-afflicted patients.
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