Invention Application
- Patent Title: SELECTIVE ANDROGEN RECEPTOR DEGRADER (SARD) LIGANDS AND METHODS OF USE THEREOF
-
Application No.: PCT/US2019/032751Application Date: 2019-05-16
-
Publication No.: WO2019222556A1Publication Date: 2019-11-21
- Inventor: NARAYANAN, Ramesh , MILLER, Duane, D. , PONNUSAMY, Thamarai , HWANG, Dong-Jin , HE, Yali
- Applicant: GTX, INC. , UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION
- Applicant Address: 175 Toyota Plaza, 7th Floor Memphis, TN 38103 US
- Assignee: GTX, INC.,UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION
- Current Assignee: GTX, INC.,UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION
- Current Assignee Address: 175 Toyota Plaza, 7th Floor Memphis, TN 38103 US
- Agency: COHEN, Mark
- Priority: US62/672,564 20180516; US62/672,558 20180516; US62/727,309 20180905
- Main IPC: A61K31/277
- IPC: A61K31/277 ; A61K31/167 ; A61K31/404 ; A61P35/00 ; A61P35/04
Abstract:
This invention is directed to selective androgen receptor degrader (SARD) compounds including heterocyclic rings and pharmaceutical compositions and uses thereof in treating prostate cancer, advanced prostate cancer, castration resistant prostate cancer, triple negative breast cancer, other cancers expressing the androgen receptor, androgenic alopecia or other hyperandrogenic dermal diseases, Kennedys disease, amyotrophic lateral sclerosis (ALS), abdominal aortic aneurysm (AAA), and uterine fibroids, and to methods for reducing the levels of androgen receptor-full length (AR-FL) including pathogenic or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.
Information query