The present invention provides antibodies and antigen-binding fragments ( e.g. , human antibodies) that bind specifically to human IL-36 receptor. Methods for treating or preventing diseases mediated by IL36R ( e.g ., skin or colon inflammatory conditions such as palmo-plantar pustular psoriasis, palmoplantar pustulosis, generalized pustular psoriasis, ulcerative colitis or IBD) using the antibodies and fragments are also provided along with methods of making the antibodies and fragments.