- 专利标题： RHODAMINE TRIPLET STATE COMPLEX AND PREPARATION AND PHOTODYNAMIC THERAPY (PDT) STUDY THEREOF
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申请号： PCT/CN2018/100896申请日： 2018-08-16
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公开(公告)号： WO2020034164A1公开(公告)日： 2020-02-20
- 发明人: WONG, Keith Man Chung , LIU, Chuangjun , GONG, Ping , ZHOU, Lihua , CAI, Lintao
- 申请人： SOUTHERN UNIVERSITY OF SCIENCE AND TECHNOLOGY , SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY CHINESE ACADEMY OF SCIENCES
- 申请人地址： No.1088, Xueyuan Blvd., Xili, Nanshan District Shenzhen, Guangdong 518055 CN
- 专利权人： SOUTHERN UNIVERSITY OF SCIENCE AND TECHNOLOGY,SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY CHINESE ACADEMY OF SCIENCES
- 当前专利权人： SOUTHERN UNIVERSITY OF SCIENCE AND TECHNOLOGY,SHENZHEN INSTITUTES OF ADVANCED TECHNOLOGY CHINESE ACADEMY OF SCIENCES
- 当前专利权人地址： No.1088, Xueyuan Blvd., Xili, Nanshan District Shenzhen, Guangdong 518055 CN
- 代理机构： BEYOND ATTORNEYS AT LAW
- 主分类号： C07F13/00
- IPC分类号： C07F13/00 ; C07F19/00 ; A61P35/00
摘要：
Through the use of a rhodamine appended chelate, a versatile strategy has been demonstrated to generate mitochondria-targeting photosensitizers via the incorporation of variety of luminescent transition metal systems. The generation of triplet excited state of rhodamine moiety endows the complexes with mitochondria-targeting photosensitizing ability to form singlet oxygen ( 1 O 2 ) for use as photodynamic therapy (PDT) agent. The combination of rhodamine organic dye and luminescent transition metal centers in such hybrid systems exhibits the synergistic merits, including low dark cytotoxicity, selective tumor cell uptake, high molar absorptivity for low-energy excitation in the visible region, and high photostability.
