An artwork production and trading management method according to an embodiment of the present invention comprises the steps of: storing information in a material in an information-in-material database, when the information in the material is received from an artist's terminal, and requesting a material producer's terminal to convert the information in the material into an artificial nucleic acid sequence and to produce an artwork material embedded with the converted artificial nucleic acid sequence; after an artwork is produced using the artwork material, receiving the artwork information and registering the received artwork information in an artwork information database; providing, to a purchaser's terminal, artwork information registered in the artwork information database, and when a purchaser selects a specific artwork through the purchaser's terminal, processing a trade of the selected artwork; and when the nucleic acid sequence information is received from the purchaser's terminal, retrieving the nucleic acid sequence information from the information-in-the-material database.