- 专利标题： USP19 INHIBITORS FOR USE IN THERAPY
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申请号： PCT/GB2019/053456申请日： 2019-12-06
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公开(公告)号： WO2020115500A1公开(公告)日： 2020-06-11
- 发明人: ROUNTREE, James Samuel Shane , HEWITT, Peter , MCFARLAND, Mary Melissa , BURKAMP, Frank , BELL, Christina , O'DOWD, Colin , HARRISON, Timothy , HELM, Matthew Duncan , ROZYKA, Ewelina , CRANSTON, Aaron , JACQ, Xavier , PROCTOR, Lauren
- 申请人： ALMAC DISCOVERY LIMITED
- 申请人地址： Almac House 20 Seagoe Industrial Estate Craigavon BT63 5QD GB
- 专利权人： ALMAC DISCOVERY LIMITED
- 当前专利权人： ALMAC DISCOVERY LIMITED
- 当前专利权人地址： Almac House 20 Seagoe Industrial Estate Craigavon BT63 5QD GB
- 代理机构： BOULT WADE TENNANT LLP
- 优先权： GB1819936.4 20181206; GB1904341.3 20190328
- 主分类号： A61K31/4545
- IPC分类号： A61K31/4545 ; A61K31/496 ; A61K31/513 ; A61K31/5377 ; A61P3/04 ; A61P5/48 ; A61P21/00 ; A61P35/00
摘要：
Provided are USP19 inhibitors, methods of treating obesity, metabolic syndrome and/or diabetes using the USP19 inhibitor compounds, as well as those compounds for use in methods of treating obesity, metabolic syndrome and/or diabetes. Also provided are methods of treating muscular atrophy, for example cachexia or sarcopenia with USP19 inhibitor compounds, plus those compounds for use in methods of treating muscular atrophy.
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