A bioenvironmental simulation device of the present invention comprises: at least one mounting unit on which cells to be measured are stably placed; a rotation force applying part for rotating the mounting unit so as to apply a rotational force to the cells to be measured, which have been stably placed on the mounting unit; and a culture fluid flow device which is configured to allow a culture fluid to flow across the mounting unit, and flows the culture fluid to apply a shear force to the cells to be measured.