Methods and systems for providing continuous renal replacement therapy (CRRT) to a patient are provided. The system includes a hemofiltration unit that provides continuous venovenous hemofiltration (CVVH), a replacement fluid flow regulator configured to regulate the flow of a replacement fluid, an anticoagulant flow regulator configured to pump an anticoagulant, and a blood warmer. The system provides enhanced access to the extracorporeal circuit for blood analysion, infusion of products and/or anticoagulation control. The system may be used to treat patients having renal insufficiency.