Disclosed is a pharmaceutical composition for controlling African swine fever, and an extraction, an injection and the use thereof. The pharmaceutical composition comprises the following raw materials in parts by weight: 10‑30 parts of ganoderma, 4‑12 parts of Drosera burmannii, 4‑12 parts of Harrisonia perforata, 30‑50 parts of Arecae semen, 4‑12 parts of Callicarpa nudiflora, 4‑12 parts of Stephania epigaea root and 4‑12 parts of nepenthes. The pharmaceutical composition has an efficient control effect on African swine fever, can be widely used to preventing the African swine fever virus, and solves a major problem of the pork industry.