Invention Application
- Patent Title: NOVEL ANTIGEN BINDING MOLECULE FORMATS
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Application No.: PCT/US2020/045309Application Date: 2020-08-07
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Publication No.: WO2021026409A1Publication Date: 2021-02-11
- Inventor: ZHANG, Tong , PYLES, Erica , ROSCONI, Michael , LIU, Nina , PATEL, Supriya , SMITH, Eric , MURPHY, Andrew , LIN, Chiayang , DAVIS, Samuel
- Applicant: REGENERON PHARMACEUTICALS, INC.
- Applicant Address: 777 Old Saw Mill River Road Tarrytown, New York 10591 US
- Assignee: REGENERON PHARMACEUTICALS, INC.
- Current Assignee: REGENERON PHARMACEUTICALS, INC.
- Current Assignee Address: 777 Old Saw Mill River Road Tarrytown, New York 10591 US
- Agency: ABU-SHAAR, Muna et al.
- Priority: US62/884,496 20190808; US63/050,483 20200710
- Main IPC: C07K16/24
- IPC: C07K16/24 ; C07K16/28 ; C07K16/46
Abstract:
Antigen binding molecules (ABMs) comprising Fab domains in non-native configurations, ABM conjugates comprising the ABMs and cytotoxic or cytostatic agents, pharmaceutical compositions containing the ABMs and ABM conjugates, methods of using the ABMs, ABM conjugates and pharmaceutical compositions for treating cancer, nucleic acids encoding the ABMs, cells engineered to express the ABMs, and methods of producing ABMs.
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