- 专利标题： IMMUNE TOLERANT ELASTIN-LIKE RECOMBINANT PEPTIDES AND METHODS OF USE
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申请号： PCT/US2020/040230申请日： 2020-06-30
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公开(公告)号： WO2021040881A1公开(公告)日： 2021-03-04
- 发明人: CHEN, Mingnan , WANG, Peng , ZHAO, Peng , DONG, Shuyun
- 申请人： UNIVERSITY OF UTAH RESEARCH FOUNDATION
- 申请人地址： 615 Arapeen Drive
- 专利权人： UNIVERSITY OF UTAH RESEARCH FOUNDATION
- 当前专利权人： UNIVERSITY OF UTAH RESEARCH FOUNDATION
- 当前专利权人地址： 615 Arapeen Drive
- 代理机构： MARTY, Scott, D. et al.
- 优先权： US62/890,936 2019-08-23
- 主分类号： A61K47/64
- IPC分类号： A61K47/64 ; A61K38/39 ; A61K47/42
摘要：
Disclosed herein, are recombinant polypeptides comprising one or more homologous amino acid repeats fused with an IgG binding domain. The recombinant polypeptides can be bound to a therapeutic antibody and used a delivery vehicle to increase the retention time and reduce systemic-related side effects of the therapeutic antibodies. Also disclosed herein are pharmaceutical compositions including the recombinant polypeptides bound to a therapeutic antibody; and methods of administering the same to patients for the treatment of cancer.
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