Invention Application
- Patent Title: METHODS AND COMPOSITIONS FOR INCREASING TRANSDUCTION EFFICIENCY WITH CELL MEMBRANE FUSION PROTEINS
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Application No.: PCT/US2020/061420Application Date: 2020-11-20
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Publication No.: WO2021102215A1Publication Date: 2021-05-27
- Inventor: LI, Chengwen , SUTTON, R. Bryan
- Applicant: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL , TEXAS TECH UNIVERSITY SYSTEM
- Applicant Address: 109 Church Street; P.O. Box 42007
- Assignee: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL,TEXAS TECH UNIVERSITY SYSTEM
- Current Assignee: THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL,TEXAS TECH UNIVERSITY SYSTEM
- Current Assignee Address: 109 Church Street; P.O. Box 42007
- Agency: SCHWARTMAN, Robert, A.
- Priority: US62/939,344 2019-11-22
- Main IPC: C12N15/85
- IPC: C12N15/85 ; C12N15/86 ; C07K14/47 ; A61K48/00 ; A61P35/00
Abstract:
The invention relates to methods and compositions for increasing introduction (e.g., transduction) efficiency. In particular, the invention relates to methods of increasing introduction (e.g., transduction) efficiency by contacting a host cell with a heterologous agent in the presence of a cell membrane fusion protein or a functional fragment or derivative thereof. The invention further relates to compositions that include a heterologous agent and a cell membrane fusion protein or a functional fragment or derivative thereof.
Information query
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