Invention Application
- Patent Title: PATATIN-LIKE PHOSPHOLIPASE DOMAIN CONTAINING 3 (PNPLA3) IRNA COMPOSITIONS AND METHODS OF USE THEREOF
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Application No.: PCT/US2020/064776Application Date: 2020-12-14
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Publication No.: WO2021126734A1Publication Date: 2021-06-24
- Inventor: TREMBLAY, Frederic , MCININCH, James, D. , CASTORENO, Adam , SCHLEGEL, Mark, K. , KAITTANIS, Charalambos
- Applicant: ALNYLAM PHARMACEUTICALS, INC.
- Applicant Address: 675 West Kendall Street
- Assignee: ALNYLAM PHARMACEUTICALS, INC.
- Current Assignee: ALNYLAM PHARMACEUTICALS, INC.
- Current Assignee Address: 675 West Kendall Street
- Agency: ZACHARAKIS, Maria, Laccotripe
- Priority: US62/948,445 2019-12-16
- Main IPC: C12N15/113
- IPC: C12N15/113 ; A61K31/713 ; A61P1/16 ; C12N15/1137 ; C12N2310/14 ; C12N2310/3183 ; C12N2310/321 ; C12N2310/322 ; C12N2310/351
Abstract:
The present invention relates to RNAi agents, e.g., double stranded RNA (dsRNA) agents, targeting the Patatin-Like Phospholipase Domain Containing 3 (PNPLA3) gene. The invention also relates to methods of using such RNAi agents to inhibit expression of a PNPLA3 gene and to methods of preventing and treating an PNPLA3 -associated disorder, e.g., Nonalcoholic Fatty Liver Disease (NAFLD).
Information query
IPC分类:
