- 专利标题： METHODS AND COMPOSITIONS FOR TREATMENT OF SARS-COV-2 INFECTION
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申请号： PCT/EP2021/058799申请日： 2021-04-02
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公开(公告)号： WO2021198511A1公开(公告)日： 2021-10-07
- 发明人: BOYER, Laurent , AUBERGER, Patrick , IVANOV, Stoyan , COURJON, Johan , POMARES, Christelle , GIORDANENGO, Valérie , VISVIKIS, Orane , LOUBATIER, Céline , VITALE, Sébastien , DUFIES, Océnane , TORRE, Cédric , DOYE, Anne , MUNRO, Patrick , LOTTE, Romain , JACQUEL, Arnaud , ROBERT, Alex
- 申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) , UNIVERSITE COTE D'AZUR , CENTRE HOSPITALIER UNIVERSITAIRE DE NICE , HOPITAL DE CANNES
- 申请人地址： 101, rue de Tolbiac; 06103 NICE; 4 avenue Reine Victoria; 15 Avenue des Broussailles CS 50008
- 专利权人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE),UNIVERSITE COTE D'AZUR,CENTRE HOSPITALIER UNIVERSITAIRE DE NICE,HOPITAL DE CANNES
- 当前专利权人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE),UNIVERSITE COTE D'AZUR,CENTRE HOSPITALIER UNIVERSITAIRE DE NICE,HOPITAL DE CANNES
- 当前专利权人地址： 101, rue de Tolbiac; 06103 NICE; 4 avenue Reine Victoria; 15 Avenue des Broussailles CS 50008
- 代理机构： INSERM TRANSFERT
- 优先权： EP20315109.7 2020-04-03
- 主分类号： A61K31/00
- IPC分类号： A61K31/00 ; A61K31/18 ; A61K31/4184 ; A61K31/64 ; A61K31/713 ; A61K45/06 ; A61K31/4706 ; A61P31/14 ; G01N33/50 ; G01N33/5047
摘要：
Inventors collect and analyze the blood of patients to determine their cytokine profile in the serum and the profile/activation status of circulating leukocytes by flow cytometry and measure inflammasomes activation using the FAM-FLICA probe that labels activated caspase-1 (that processes pro-IL-1β in mature IL-1β). Moreover, inventors describes that a use of a specific NLRP3 inhibitor (MCC950) allows them to determine that the activation observed in the blood samples is NLRP3 dependent. Accordingly, the invention relates to NLRP3 inhibitors for use in the treatment of SARS-CoV-2 infection and SARS-CoV-2 related disorders in a subject in need thereof.
